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Environmental and Toxicological Aspects of Insect Growth Regulators
James E. Wright
Environmental Health Perspectives
Vol. 14 (Apr., 1976), pp. 127-132
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3428370
Page Count: 6
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Insect growth regulators (IGRs) are a class of new chemicals that interfere with maturation and reproduction in insects. Proposed hypotheses on the biochemical mechanism of action are presented herein. The environmental aspects as metabolism in soils, plants, insects, and animals suggest strongly that these chemicals undergo rapid degradation and metabolism to innocuous metabolites. The toxicological properties determined for registration of the IGR methoprene, isopropyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate, reflected no significant effects against any of the species tested. Toxicological evaluations in swine, sheep, hamsters, rats, dogs, rabbits, guinea pigs, and cattle revealed no clinical signs of toxicosis. Additionally, teratological studies in swine, sheep, hamsters, rats, and rabbits also resulted in no observable effects in the animals at the levels administered.
Environmental Health Perspectives © 1976 The National Institute of Environmental Health Sciences