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Metabolism and Toxicology of Pyrethroids with Dihalovinyl Substituents

Luis O. Ruzo and John E. Casida
Environmental Health Perspectives
Vol. 21 (Dec., 1977), pp. 285-292
DOI: 10.2307/3428535
Stable URL: http://www.jstor.org/stable/3428535
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Metabolism and Toxicology of Pyrethroids with Dihalovinyl Substituents
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Abstract

Replacement of the photolabile and biodegradable isobutenyl substituent of pyrethroids with a dihalovinyl group often leads to improved insecticidal potency and enhanced photostability. This type of structural modification does not greatly alter the ease of detoxification in mammals since other sites in the molecule undergo metabolic attack. The available toxicological information on dihalovinyl pyrethroids indicates that they are suitable replacements for other insecticides with less favorable persistence and toxicological characteristics.

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