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Increased Urinary β 2-Microglobulin in Cadmium Exposure: Dose-Effect Relationship and Biological Significance of β 2-Microglobulin

Kenzaburo Tsuchiya, Soichiro Iwao, Monoru Sugita and Haruhiko Sakurai
Environmental Health Perspectives
Vol. 28 (Feb., 1979), pp. 147-153
DOI: 10.2307/3428917
Stable URL: http://www.jstor.org/stable/3428917
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Increased Urinary β 2-Microglobulin in Cadmium Exposure: Dose-Effect Relationship and Biological Significance of β 2-Microglobulin
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Abstract

A study on the general population from both cadmium-polluted and control areas and on cadmium alloy workers indicates that β 2- MG in urine is very closely correlated with aging, but it indicates an association with cadmium exposure. However, the age factor is stronger than cadmium exposure in both polluted and control areas among persons without clinical proteinuria. On the other hand, cadmium exposure is most likely correlated with β 2- MG even in nonpolluted areas. Thus it seems that there is no noneffect level of cadmium dose in affecting the elevation of β 2- MG in urine. β 2- MG in serum indicated a very close correlation with cadmium in blood among cadmium alloy workers. This may suggest that an increase of β 2- MG in both blood and urine in an early stage of cadmium exposure is caused by the increased level of β 2- MG in blood, which may be a result of stimulation due to cadmium, but not necessarily by the clinical dysfunction of reabsorption of β 2- MG in the renal tubules.

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