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Analysis of Mitotic Nondisjunction with Aspergillus nidulans

G. Morpurgo, D. Bellincampi, G. Gualandi, L. Baldinelli and O. Serlupi Crescenzi
Environmental Health Perspectives
Vol. 31 (Aug., 1979), pp. 81-95
DOI: 10.2307/3429146
Stable URL: http://www.jstor.org/stable/3429146
Page Count: 15
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Analysis of Mitotic Nondisjunction with Aspergillus nidulans
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Abstract

Two methods to detect the induction of nondisjunction with a diploid stable strain of A. nidulans are described. The first method gives only qualitative results, while the second method is quantitative and dose-effect curves can be done. Some physiological parameters affecting the induction of nondisjunction can also be studied, because either quiescent or germinating conidia can be treated with the drug under test. Some agents inducing nondisjunction were also tested for the induction of point mutation and somatic crossing-over with these comparative analysis. Two classes of agents inducing nondisjunction may be detected: the first causes all possible types of genetic damage either on quiescent or germinating conidia (a representative of this class is MMS) and acts presumably on the DNA level; the second acts only on germinating conidia and does not produce point mutation or crossing over. A representative of this class is Benomyl which interferes with spindle microtubules. A list of compounds tests is included.

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