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Review of Pulmonary Effects of Poly(Vinyl Chloride) and Vinyl Chloride Exposure

Ruth Lilis
Environmental Health Perspectives
Vol. 41 (Oct., 1981), pp. 167-169
DOI: 10.2307/3429311
Stable URL: http://www.jstor.org/stable/3429311
Page Count: 3
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Review of Pulmonary Effects of Poly(Vinyl Chloride) and Vinyl Chloride Exposure
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Abstract

The contributions of several recent reports to the definition of pulmonary effects of PVC dust inhalation are reviewed. Granulomatous reaction, with inclusion of PVC particles in macrophages and histocytes, and associated interstitial pulmonary fibrosis have been found to lead to exertional dyspnoea, diffuse micronodular chest radiographic opacities and restrictive pulmonary dysfunction. The effects of vinyl chloride (VC) monomer (gas) on proteins and the immunologic mechanisms triggered by the altered protein are possible mechanisms for the development in some cases of interstitial pulmonary fibrosis secondary to VC exposure. Vinyl chloride, a confirmed carcinogen, has been associated with, among other malignant tumors, a significant increase in the incidence of lung cancer. The magnitude of this effect has not yet been completely evaluated.

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