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Toxicity of Mycotoxins for the Rat Pulmonary Macrophage in Vitro

W. G. Sorenson, G. Frank Gerberick, Daniel M. Lewis and Vincent Castranova
Environmental Health Perspectives
Vol. 66 (Apr., 1986), pp. 45-53
DOI: 10.2307/3430213
Stable URL: http://www.jstor.org/stable/3430213
Page Count: 9
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Toxicity of Mycotoxins for the Rat Pulmonary Macrophage in Vitro
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Abstract

The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers.

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