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In Vivo Mutations in Human Blood Cells: Biomarkers for Molecular Epidemiology

Richard J. Albertini, Janice A. Nicklas, James C. Fuscoe, Thomas R. Skopek, Richard F. Branda and J. Patrick O'Neill
Environmental Health Perspectives
Vol. 99 (Mar., 1993), pp. 135-141
DOI: 10.2307/3431469
Stable URL: http://www.jstor.org/stable/3431469
Page Count: 7
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In Vivo Mutations in Human Blood Cells: Biomarkers for Molecular Epidemiology
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Abstract

Mutations arising in vivo in recorder genes of human blood cells provide biomarkers for molecular epidemiology by serving as surrogates for cancer-causing genetic changes. Current markers include mutations of the glycophorin-A (GPA) or hemoglobin (Hb) genes, measured in red blood cells, or mutations of the hypoxanthine-guanine phosphoribosyltransferase (hprt) or HLA genes, measured in T-lymphocytes. Mean mutant frequencies (variant frequencies) for normal young adults are approximately: ${\rm Hb}(4\times 10^{-8})

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