You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Vanadium Distribution in Rats and DNA Cleavage by Vanadyl Complex: Implication for Vanadium Toxicity and Biological Effects
Environmental Health Perspectives
Vol. 102, Supplement 3: Molecular Mechanisms of Metal Toxicity and Carcinogenicity (Sep., 1994), pp. 35-36
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3431759
Page Count: 2
You can always find the topics here!Topics: Vanadium, Vanadates, DNA cleavage, Electron paramagnetic resonance, Hydrogen, Rats, Liver, Toxicity, Vanadium compounds, Dosage
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Preview not available
Vanadium ion is toxic to animals. However, vanadium is also an agent used for chemoprotection against cancers in animals. To understand both the toxic and beneficial effects we studied vanadium distribution in rats. Accumulation of vanadium in the liver nuclei of rats given low doses of compounds in the +4 or +5 oxidation state was greater than in the liver nuclei of rats given high doses of vanadium compounds or the vanadate (+5 oxidation state) compound. Vanadium was incorporated exclusively in the vanadyl (+4 oxidation state) form. We also investigated the reactions of vanadyl ion and found that incubation of DNA with vanadyl ion and hydrogen peroxide ( H2 O2) led to intense DNA cleavage. ESR spin trapping demonstrated that hydroxyl radicals are generated during the reactions of vanadyl ion and H2 O2. Thus, we propose that the mechanism for vanadium-dependent toxicity and antineoplastic action is due to DNA cleavage by hydroxyl radicals generated in living systems.
Environmental Health Perspectives © 1994 The National Institute of Environmental Health Sciences