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Three-Dimensional Visualization of Physiologically Based Kinetic Model Outputs
John Nichols, Penny Rheingans, Douglas Lothenbach, Robert McGeachie, Loren Skow and James McKim
Environmental Health Perspectives
Vol. 102, No. 11 (Nov., 1994), pp. 952-956
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3431917
Page Count: 5
You can always find the topics here!Topics: Chemicals, Trout, Drug design, Kinetics, Rainbows, Modeling, Body tissues, Environmental health, Risk analysis, Toxicity
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Outputs from a physiologically based toxicokinetic (PB-TK) model for fish were visualized by mapping time-series data for specific tissues onto a three-dimensional representation of a rainbow trout. The trout representation was generated in stepwise fashion: 1) cross-sectional images were obtained from an anesthetized fish using a magnetic resonance imaging system, 2) images were processed to classify tissue types and eliminate unnecessary detail, 3) processed images were imported to a visualization software package (Application Visualization System) to create a three-dimensional representation of the fish, encapsulating five volumes corresponding to the liver, kidney, muscle, gastrointestinal tract, and fat. Kinetic data for the disposition of pentachloroethane in trout were generated using a PB-TK model. Model outputs were mapped onto corresponding tissue volumes, representing chemical concentration as color intensity. The workstation software was then used to animate the images, illustrating the accumulation of pentachloroethane in each tissue during a continuous branchial (gill) exposure.
Environmental Health Perspectives © 1994 The National Institute of Environmental Health Sciences