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8-Hydroxydeoxyguanosine in Human Leukocyte DNA and Daily Health Practice Factors: Effects of Individual Alcohol Sensitivity

Madoka Nakajima, Toru Takeuchi, Tatsuya Takeshita and Kanehisa Morimoto
Environmental Health Perspectives
Vol. 104, No. 12 (Dec., 1996), pp. 1336-1338
DOI: 10.2307/3432971
Stable URL: http://www.jstor.org/stable/3432971
Page Count: 3
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
8-Hydroxydeoxyguanosine in Human Leukocyte DNA and Daily Health Practice Factors: Effects of Individual Alcohol Sensitivity
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Abstract

A typical oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was evaluated in human polymorphonuclear leukocytes (PMN) and mononuclear leukocytes (MN) by an anaerobic determination method. The mean 8-OHdG values were the lowest level ever reported [PMN, 3.07 ± 1.45; MN, 2.37 ± 1.21 8- OHdG/106 deoxyguanosine molecules (dG); n = 92]. According to a self-administered questionnaire to 92 healthy male workers, the relationship was investigated between 8-OHdG in leukocytes and daily health practice factors, that is, the frequency of physical exercise, smoking status, alcohol drinking, nutritional balance, and the degree of mental stress. A significant difference was observed only in alcohol drinking in subjects classified by aldehyde-dehydrogenase 2 isozyme (ALDH2) genotype. Habitual alcohol intake appeared to increase 8-OHdG in PMN from ALDH2-deficient subjects. Neither age, body mass index, nor any other factors examined showed any significant correlation with the 8-OHdG levels in leukocytes.

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