You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
8-Hydroxydeoxyguanosine in Human Leukocyte DNA and Daily Health Practice Factors: Effects of Individual Alcohol Sensitivity
Madoka Nakajima, Toru Takeuchi, Tatsuya Takeshita and Kanehisa Morimoto
Environmental Health Perspectives
Vol. 104, No. 12 (Dec., 1996), pp. 1336-1338
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3432971
Page Count: 3
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
A typical oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was evaluated in human polymorphonuclear leukocytes (PMN) and mononuclear leukocytes (MN) by an anaerobic determination method. The mean 8-OHdG values were the lowest level ever reported [PMN, 3.07 ± 1.45; MN, 2.37 ± 1.21 8- OHdG/106 deoxyguanosine molecules (dG); n = 92]. According to a self-administered questionnaire to 92 healthy male workers, the relationship was investigated between 8-OHdG in leukocytes and daily health practice factors, that is, the frequency of physical exercise, smoking status, alcohol drinking, nutritional balance, and the degree of mental stress. A significant difference was observed only in alcohol drinking in subjects classified by aldehyde-dehydrogenase 2 isozyme (ALDH2) genotype. Habitual alcohol intake appeared to increase 8-OHdG in PMN from ALDH2-deficient subjects. Neither age, body mass index, nor any other factors examined showed any significant correlation with the 8-OHdG levels in leukocytes.
Environmental Health Perspectives © 1996 The National Institute of Environmental Health Sciences