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Metabolism of Hexachlorobenzene in Humans: Association between Serum Levels and Urinary Metabolites in a Highly Exposed Population

Jordi To-Figueras, Maria Sala, Raquel Otero, Carme Barrot, Mary Santiago-Silva, Miquel Rodamilans, Carme Herrero, Joan Grimalt and Jordi Sunyer
Environmental Health Perspectives
Vol. 105, No. 1 (Jan., 1997), pp. 78-83
DOI: 10.2307/3433066
Stable URL: http://www.jstor.org/stable/3433066
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Metabolism of Hexachlorobenzene in Humans: Association between Serum Levels and Urinary Metabolites in a Highly Exposed Population
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Abstract

Serum and urine from 100 subjects of a general population highly exposed to airborne hexachlorobenzene (HCB) were analyzed to obtain new insights into the metabolism of this ubiquitous compound. HCB was detected in all serum samples with concentrations ranging between 1.1 and 953 ng/ml. The major known metabolites of HCB were investigated in urine collected over 24 hr. Pentachlorophenol (PCP) was detected in all urines with values ranging between 0.58 and 13.9 μg excreted in 24 hr [mean ± standard deviation (SD), 2.52 ± 2.05; geometric mean, 2.05]. A sulfur derivative that, after hydrolysis, yielded pentachlorobenzenethiol (PCBT) could also be identified and quantified in all the urines with values ranging between 0.18 and 84.0 μg of PCBT excreted in 24 hr (mean ± SD, 3.47 ± 10.8; geometric mean, 1.39). The sulfer derivative assessed as PCBT appeared to be the main metabolite, with urinary concentrations surpassing those of PCP in the subjects with higher HCB accumulation (HCB in serum >32 ng/ml). PCBT concentration in urine collected over 24 hr showed a very strong association with HCB concentration in serum; the association was stronger in males than in females. An increase of 1 ng/ml of HCB in serum led to an increase of 2.12 μg of PCBT excreted in urine collected over 24 hr in males (95% CI, 1.82-2.44) and to an increase of 0.67 μg of PCBT in females (CI, 0.33-1.09). A weaker association was found between PCP in urine and HCB in serum, which was only statistically significant in males (an increase of 1 ng/ml of HCB in serum led to an increase of 0.63 μg of PCP excreted in urine collected over 24 hr; (CI, 0.34-0.95). These results show that the formation of the cysteine conjugate is a quantitatively more important metabolic pathway in humans than the formation of PCP. Moreover, the association found suggests that PCBT is a good urinary marker of HCB internal dose and glutathione-mediated metabolism.

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