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The Challenge Posed by Endocrine-Disrupting Chemicals

John Ashby, Erik Houthoff, Sandy J. Kennedy, Jim Stevens, Rémi Bars, Friedrich W. Jekat, Pamela Campbell, Jim Van Miller, Francis M. Carpanini and Geoffrey L. P. Randall
Environmental Health Perspectives
Vol. 105, No. 2 (Feb., 1997), pp. 164-169
DOI: 10.2307/3433233
Stable URL: http://www.jstor.org/stable/3433233
Page Count: 6
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The Challenge Posed by Endocrine-Disrupting Chemicals
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Abstract

Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literature. A list of priorities is provided, including the need for additional epidemiological and wildlife studies, the derivation of a coordinated testing strategy, agreement on the toxicities expected of endocrine disrupting agents, and acceptance that whole animal assays will be uniquely critical in this area of toxicology. The intrinsic difficulty of attempting to simultaneously study all aspects of endocrine disruption indicates the need to reduce the scope of the problem, which can be achieved by first studying toxicities mediated by sex hormone receptors.

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