You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Cell Size of Alveolar Macrophages: An Interspecies Comparison
Fritz Krombach, Silvia Münzing, Anne-Marie Allmeling, J. Tilman Gerlach, Jürgen Behr and Martina Dörger
Environmental Health Perspectives
Vol. 105, Supplement 5: Particle Toxicity (Sep., 1997), pp. 1261-1263
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3433544
Page Count: 3
You can always find the topics here!Topics: Rats, Alveolar macrophages, Hamsters, Humans, Species, Lungs, Monkeys, Diameters, Species differences, Bronchoalveolar lavage
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Alveolar macrophages (AM) play a critical role in the removal of inhaled particles or fibers from the lung. Species differences in AM size may affect the number and size range of particles/fibers that can be actually phagocytized and cleared by AM. The purpose of this study was to compare the cell size of rat, hamster, monkey, and human AM by selective flow cytometric analysis of cell volume. Resident AM from CD rats, Syrian golden hamsters, cynomolgus monkeys, and nonsmoking, healthy human volunteers were harvested by standard bronchoalveolar lavage procedures. Morphometric analysis of AM was performed using a flow cytometer that generates volume signals based on the Coulter-type measurement of electrical resistance. We found that hamster and rat AM had diameters of 13.6 ± 0.4 μm (n = 8) and 13.1 ± 0.2 μm (n = 12), respectively. Comparatively, the AM from monkeys (15.3 ± 0.5 μm, n = 7) and human volunteers (21.2 ± 0.3 μm, n = 10) were larger than those from rats and hamsters. The AM from humans were significantly larger (p < 0.05) than those from all other species studied, corresponding to a 4-fold larger cell, volume of human AM (4990± 174 μ m3) compared to hamster (1328± 123 μ m3) and rat (1166± 42 μ m3) AM. In summary, we have found marked species differences in the cell size of AM. We suggest that the number and size range of particles/fibers that can be phagocytized and cleared by AM may differ among species due to inherent or acquired species differences in AM cell size.
Environmental Health Perspectives © 1997 The National Institute of Environmental Health Sciences