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Quantitative Mechanistically Based Dose-Response Modeling with Endocrine-Active Compounds

Melvin E. Andersen, Rory B. Conolly, Elaine M. Faustman, Robert J. Kavlock, Christopher J. Portier, Daniel M. Sheehan, Patrick J. Wier and Lauren Ziese
Environmental Health Perspectives
Vol. 107, Supplement 4 (Aug., 1999), pp. 631-638
DOI: 10.2307/3434556
Stable URL: http://www.jstor.org/stable/3434556
Page Count: 8
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Quantitative Mechanistically Based Dose-Response Modeling with Endocrine-Active Compounds
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Abstract

A wide range of toxicity test methods is used or is being developed for assessing the impact of endocrine-active compounds (EACs) on human health. Interpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically based dose-response (MBDR) models to assist low-dose, interspecies, and in vitro to in vivo extrapolations. A quantitative dose-response modeling work group examined the state of the art for developing MBDR models for EACs and the near-term needs to develop, validate, and apply these models for risk assessments. Major aspects of this report relate to current status of these models, the objectives/goals in MBDR model development for EACs, low-dose extrapolation issues, regulatory inertia impeding acceptance of these approaches, and resource/data needs to accelerate model development and model acceptance by the research and the regulatory community.

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