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Advances in Uterine Leiomyoma Research: The Progesterone Hypothesis
Mitchell S. Rein
Environmental Health Perspectives
Vol. 108, Supplement 5 (Oct., 2000), pp. 791-793
Published by: The National Institute of Environmental Health Sciences
Stable URL: http://www.jstor.org/stable/3454308
Page Count: 3
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Uterine leiomyomas are monoclonal tumors. However, the factors involved in their initiation and growth remain poorly understood. The neoplastic transformation of myometrium to leiomyoma likely involves somatic mutations of normal myometrium and the complex interactions of sex steroids and local growth factors. Traditionally, estrogen has been considered the major promoter of myoma growth. The purpose of this review is to highlight the biochemical, histologic, and clinical evidence that supports an equally important role for progesterone in the growth of uterine myomas. Biochemical studies suggest that progesterone, progestins, and the progesterone receptor modulate myoma mitotic activity. A hypothesis to explain the pathogenesis of myomas is presented.
Environmental Health Perspectives © 2000 The National Institute of Environmental Health Sciences