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A Journey from Neocortex to Hippocampus

Tim V. P. Bliss
Philosophical Transactions: Biological Sciences
Vol. 358, No. 1432, Long-term Potentiation: Enhancing Neuroscience for 30 Years (Apr. 29, 2003), pp. 621-623
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/3558159
Page Count: 3
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A Journey from Neocortex to Hippocampus
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Abstract

In the mid-1960s, it was generally agreed that the engram, the neural trace of previously experienced events, must be encoded by Hebb-like neurons in which synaptic efficacy could be modified by activity. Here, I describe my attempts as a PhD student at McGill University, Montreal, to find rules governing cortical plasticity in the neocortex, and having failed, why the hippocampus seemed to offer a far better prospect.

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