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Long-Term Potentiation and the Ageing Brain
C. A. Barnes
Philosophical Transactions: Biological Sciences
Vol. 358, No. 1432, Long-term Potentiation: Enhancing Neuroscience for 30 Years (Apr. 29, 2003), pp. 765-772
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/3558178
Page Count: 8
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Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
Philosophical Transactions: Biological Sciences © 2003 Royal Society