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Long-Term Potentiation and the Ageing Brain

C. A. Barnes
Philosophical Transactions: Biological Sciences
Vol. 358, No. 1432, Long-term Potentiation: Enhancing Neuroscience for 30 Years (Apr. 29, 2003), pp. 765-772
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/3558178
Page Count: 8
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Long-Term Potentiation and the Ageing Brain
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Abstract

Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

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