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Pharmacological Responses in Irradiated Animals

John Doull
Radiation Research
Vol. 30, No. 2 (Feb., 1967), pp. 333-341
DOI: 10.2307/3572060
Stable URL: http://www.jstor.org/stable/3572060
Page Count: 9
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Pharmacological Responses in Irradiated Animals
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Abstract

Alteration of drug response as a consequence of radiation exposure appears to be the exception rather than the rule for most classes of drugs. Irradiated animals exhibit few qualitative or quantitative changes in their response to therapeutic or toxic dosage levels of the commonly used anesthetics, analgesics, muscle relaxants, antihistaminics, cardiac drugs, anti-thyroid agents, diuretics, cholinergic agents, and most autonomic drugs. Where abnormal pharmacological responses occur with drugs from these classes, they can often be attributed to the secondary effects of radiation (hypotension, altered intestinal motility, etc.) rather than to any change in the manner in which the drug acts. Changes in the type of response, as well as in the magnitude of the drug effect, may occur where irradiation alters drug metabolism. The detection of such qualitative changes and a more precise characterization of those quantitative changes that have been shown to occur in irradiated animals would be of considerable practical and theoretical interest to the radiotherapist and the radiobiologist.

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