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On the Relationship between Genetic and Somatic Sensitivity to Radiation Damage in Inbred Mouse Strains

John B. Storer
Radiation Research
Vol. 31, No. 4 (Aug., 1967), pp. 699-705
DOI: 10.2307/3572337
Stable URL: http://www.jstor.org/stable/3572337
Page Count: 7
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On the Relationship between Genetic and Somatic Sensitivity to Radiation Damage in Inbred Mouse Strains
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Abstract

The incidence of dominant lethal mutations in spermatozoa estimated by postimplantation death in embryos sired by male mice irradiated with 600 R and mated one day later to female mice of the same strain or to C57BL/6J female mice was measured in four strains known to differ in somatic radiation sensitivity. In the inbred embryos (from matings between mice of the same strain) there were significant differences in embryonic mortality with the ordering of sensitivity identical to the ordering of the somatic radiation sensitivity of adults of the same strain. When the embryos were hybrids (from matings to C57BL/6J females) there were no significant differences in mortality. It was concluded that there were no strain differences in the susceptibility to the induction of chromosome damage in spermatozoa, but that radiosensitive strains were more sensitive to the induced damage, and lethality in radiosensitive strains resulted from injury which was sublethal in radioresistant strains.

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