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An Evaluation by Alpha-Particle Bragg Peak Radiation of the Critical Depth in the Rat Skin for Tumor Induction
Richard D. Heimbach, Fredric J. Burns and Roy E. Albert
Vol. 39, No. 2 (Aug., 1969), pp. 332-344
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3572670
Page Count: 13
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The production of skin tumors and chronic follicle damage in the rat was determined following graded single doses of 37-MeV alpha-particle radiation in two depth-dose patterns: (1) with the Bragg peak placed at each of three depths in skin corresponding to the regions above, below, and at the tips of the resting hair follicle and (2) with the alpha beam modified to produce a linear depth-dose pattern. Dissimilar dose-response curves for tumors and atrophic follicles were obtained for the various depth-dose patterns when the dose was expressed in terms of the maximum dose to either the skin or the follicles or as the average follicle dose. However, the dose-response curves for all the irradiation patterns became congruent when the dose was expressed as the minimum dose to the hair follicles. The results suggest that the production of chronic follicle injury and tumor induction depends on inflicting radiation damage to the entire hair follicle and that the minimally damaged region, regardless of its location, controls the overall response.
Radiation Research © 1969 Radiation Research Society