You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The Effects of X-Irradiation on Lactate Dehydrogenase Isozymes in Plasma and in Various Organs of Mice
Yasuharu Hori, Yasuhiko Takamori and Kazuo Nishio
Vol. 43, No. 1 (Jul., 1970), pp. 143-151
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3572865
Page Count: 9
You can always find the topics here!Topics: Enzymes, Blood plasma, Irradiation, Spleen, Lactates, Dehydrogenases, Liver, Electrophoresis, Braking radiation, Blood
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Male mice of the RF strain, 6-8 weeks old, were given a single exposure to whole-body x-irradiation. Lactate dehydrogenase isozymes in plasma and in various organs were separated by means of disc-gel electrophoresis. An increase of M-LDH fractions was observed in the plasma of mice a few hours after irradiation with sublethal or lethal dose. This was also proved by the experiments of substrate inhibition by pyruvate. This alteration in the composition of plasma LDH isozymes occurred coincidentally with the changes in total plasma LDH activity. LDH isozyme patterns in organs showed no remarkable change at 6 hours after exposure to 1000 R, though radiosensitive thymus and spleen exhibited a marked loss of LDH activity after exposure. In the split-dose study, no noticeable change in plasma LDH isozyme patterns was found after the second exposure. From these results it is assumed that the radiosensitive cells containing the preponderance of M-LDH fractions may be possible sources of the increased amounts of plasma LDH after exposure.
Radiation Research © 1970 Radiation Research Society