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Radioresistance in Hamsters during Hypothermic Depressed Metabolism Induced with Helium and Low Temperatures

X. J. Musacchia, W. A. Volkert and R. E. Barr
Radiation Research
Vol. 46, No. 2 (May, 1971), pp. 353-361
DOI: 10.2307/3573026
Stable URL: http://www.jstor.org/stable/3573026
Page Count: 9
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Radioresistance in Hamsters during Hypothermic Depressed Metabolism Induced with Helium and Low Temperatures
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Abstract

Hypothermic and active (normothermic) golden and albino hamsters were given whole-body exposures to ionizing radiation with a 60 Co irradiator. Hypothermia to body temperature ca. 7°C was induced using a helox-cold technique (80% helium, 20% oxygen, and 0°C ambient temperature). The radiation doses ranged from 600 to 5000 rads. Increased radioresistance was evident in the metabolically depressed hypothermic hamsters. Over a range of exposures up to 2000 rads, hypothermic hamsters showed increased mean survival times. Percent survival data for each type of hamster gave respective ${\rm LD}_{50(90)}$ values of 1067 ± 24 and 875 ± 15 for hypothermic and active golden hamsters, and 1143 ± 99 and 867 ± 34 for hypothermic and active albino hamsters. Dose-reduction factors were approximately 1.22 and 1.31. The increased radioresistance was examined in light of limited hypoxia and general metabolic depression.

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