## Access

You are not currently logged in.

Access JSTOR through your library or other institution:

## If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Journal Article

# Structure-Function Studies of the Aminothiol Radioprotectants. Effect of Carbon Chain Length in Mercaptoethylamine Homologs: Mammalian Radioprotection

Marie M. Grenan and Edmund S. Copeland
Vol. 47, No. 2 (Aug., 1971), pp. 387-391
DOI: 10.2307/3573245
Stable URL: http://www.jstor.org/stable/3573245
Page Count: 5

#### Select the topics that are inaccurate.

The relation between chemical structure and radiation protection in mice has been studied for a series of aminothiols. The aminothiols used in this study were β-mercaptoethylamine (MEA) and its propyl, butyl, pentyl, and hexyl homologs. Mice were given equimolar quantities of these drugs 15 minutes before gamma irradiation at their ${\rm LD}_{70(30)}$ (875 rads). At the radiation and drug doses employed, only MEA showed a radioprotective effect. This result is in marked contrast to those of previous studies in bacteria where pharmacological effects were avoided and only physical-chemical effects were studied.