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Structure-Function Studies of the Aminothiol Radioprotectants. Effect of Carbon Chain Length in Mercaptoethylamine Homologs: Mammalian Radioprotection

Marie M. Grenan and Edmund S. Copeland
Radiation Research
Vol. 47, No. 2 (Aug., 1971), pp. 387-391
DOI: 10.2307/3573245
Stable URL: http://www.jstor.org/stable/3573245
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Structure-Function Studies of the Aminothiol Radioprotectants. Effect of Carbon Chain Length in Mercaptoethylamine Homologs: Mammalian Radioprotection
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Abstract

The relation between chemical structure and radiation protection in mice has been studied for a series of aminothiols. The aminothiols used in this study were β-mercaptoethylamine (MEA) and its propyl, butyl, pentyl, and hexyl homologs. Mice were given equimolar quantities of these drugs 15 minutes before gamma irradiation at their ${\rm LD}_{70(30)}$ (875 rads). At the radiation and drug doses employed, only MEA showed a radioprotective effect. This result is in marked contrast to those of previous studies in bacteria where pharmacological effects were avoided and only physical-chemical effects were studied.

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