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Toxicity of ${}^{137}{\rm CsCl}$ in the Beagle. Early Biological Effects

H. C. Redman, R. O. McClellan, R. K. Jones, B. B. Boecker, T. L. Chiffelle, J. A. Pickrell and E. W. Rypka
Radiation Research
Vol. 50, No. 3 (Jun., 1972), pp. 629-648
DOI: 10.2307/3573559
Stable URL: http://www.jstor.org/stable/3573559
Page Count: 20
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Toxicity of ${}^{137}{\rm CsCl}$ in the Beagle. Early Biological Effects
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Abstract

The toxicity of ${}^{137}{\rm CsCl}$, because of a relatively uniform whole-body exposure, has been investigated as part of a program to evaluate the biological effects of internally deposited radionuclides. Sixty-six beagles (12-14 months of age) were given ${}^{137}{\rm CsCl}$ in saline iv to provide one group of six dogs with mean initial body burdens of 3800 μCi ${}^{137}{\rm Cs}/{\rm kg}$ and five groups of 12 dogs each with mean initial body burdens of 2800, 1900, 1400, 970, and 0 μCi ${}^{137}{\rm CsCl}$. Eleven dogs have died at less than 1 year postinjection: the six at the highest level between 19 and 33 days with cumulative whole-body doses of 950-1400 rads; four in the 2800 μCi/kg group between 24 and 81 days with cumulative whole-body doses of 860-1400 rads; and one at 77 days in the 1900 μCi/kg group with a cumulative whole-body dose of 1300 rads. Prior to death, all dogs became febrile, anorexic, hemorrhagic, lethargic, dehydrated, and, in some cases, developed diarrhea. The remaining 55 dogs in the study were alive at 1 year or more postinjection. A dose-related depression in the lymphocytes, granulocytes, and platelet values was observed in all groups; a similar depression in packed cell volume was noted only at the three highest levels. There was a dose-related decrease in the serum lactic acid dehydrogenase values in all dogs that died. The clinical and pathological alterations observed during the first year postinjection are described in relationship to the radiation dose.

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