Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Chromosome Aberrations in Uranium Miners Occupationally Exposed to ${}^{222}\text{Radon}$

William F. Brandom, Geno Saccomanno, Victor E. Archer, Philip G. Archer and Marilyn E. Coors
Radiation Research
Vol. 52, No. 1 (Oct., 1972), pp. 204-215
DOI: 10.2307/3573600
Stable URL: http://www.jstor.org/stable/3573600
Page Count: 12
  • Read Online (Free)
  • Download ($10.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Chromosome Aberrations in Uranium Miners Occupationally Exposed to ${}^{222}\text{Radon}$
Preview not available

Abstract

Cultures of peripheral blood leukocytes were examined from 15 uranium miners occupationally exposed to long-lived ${}^{222}\text{radon}$ daughters and 15 normal age-matched, nonminer male controls. Mining experience was from 1 to 28 years and estimated cumulative exposure was from 10 to 5400 work level months. Hyperdiploid cells occurred with twice the frequency in uranium miners compared to control cells (2.13 vs 1.60%). Cells with chromatid gaps, chromatid breaks and isochromatid gaps (B cells) also occurred with twice the frequency in uranium miner cells compared with control cells (12.9 vs 6.43%). The prevalence of "stable" cell aberrations such as abnormal monocentrics, deletions, and translocations was 0.0% in the controls and 0.13% in the miners. A documented indicator of radiation-induced chromosome aberration is the "unstable" cell aberration grouping. Dicentrics, rings, acentric fragments, and isochromatid breaks occurred at a frequency of 0.21% in the controls and 2.58% in the miners. All of the miners had cells with one or more of the "unstable" cell aberrations but cells of only three of the controls had this classification of chromosomal change and all of these were of the acentric fragment type. The differences between miners and controls in the prevalence of lymphocyte chromosome aberrations are statistically significant as well as of a magnitude that could be of biological importance. The findings are consistent with the conclusion that nonpulmonary cells of the miners undergo mutational changes as a consequence of exposure to radiation encountered in uranium mines.

Page Thumbnails

  • Thumbnail: Page 
204
    204
  • Thumbnail: Page 
205
    205
  • Thumbnail: Page 
206
    206
  • Thumbnail: Page 
207
    207
  • Thumbnail: Page 
208
    208
  • Thumbnail: Page 
209
    209
  • Thumbnail: Page 
210
    210
  • Thumbnail: Page 
211
    211
  • Thumbnail: Page 
212
    212
  • Thumbnail: Page 
213
    213
  • Thumbnail: Page 
214
    214
  • Thumbnail: Page 
215
    215