Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

The Radiation Decomposition of Phosphorothioate Protective Agents

David Martin, George Kollmann and Bernard Shapiro
Radiation Research
Vol. 56, No. 2 (Nov., 1973), pp. 246-257
DOI: 10.2307/3573663
Stable URL: http://www.jstor.org/stable/3573663
Page Count: 12
  • Read Online (Free)
  • Download ($10.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The Radiation Decomposition of Phosphorothioate Protective Agents
Preview not available

Abstract

Aqueous buffered solutions of 2-(5-aminopentyl)aminoethyl-phosphorothioate (WR-2823) and 2-(3-aminopropyl)aminoethyl-phosphorothioate (WR-2721) as well as some of their "latent derivatives" (corresponding thiols and disulfides), labeled with 35 S and 32 P, were irradiated by a 400 Ci 137 Cs γ-ray source. The radiation products were separated, identified and measured quantitatively by paper chromatography. The radiolysis of these compounds brought about oxidation of the sulfur atom with subsequent dephosphorylation, and then further oxidation occurred to either the sulfonic acid or to inorganic sulfate. The oxidation of these radiation protective agents indicates that they are capable of reacting with radicals formed in irradiated aqueous solutions thus offering partial protection against irradiation induced changes. This protection was shown in two systems in vitro: (a) radiation-induced permeability of erythrocyte membranes and (b) radiation-induced decrease in specific viscosity of DNA solutions.

Page Thumbnails

  • Thumbnail: Page 
246
    246
  • Thumbnail: Page 
247
    247
  • Thumbnail: Page 
248
    248
  • Thumbnail: Page 
249
    249
  • Thumbnail: Page 
250
    250
  • Thumbnail: Page 
251
    251
  • Thumbnail: Page 
252
    252
  • Thumbnail: Page 
253
    253
  • Thumbnail: Page 
254
    254
  • Thumbnail: Page 
255
    255
  • Thumbnail: Page 
256
    256
  • Thumbnail: Page 
257
    257