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The Radiation Decomposition of Phosphorothioate Protective Agents
David Martin, George Kollmann and Bernard Shapiro
Vol. 56, No. 2 (Nov., 1973), pp. 246-257
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3573663
Page Count: 12
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Aqueous buffered solutions of 2-(5-aminopentyl)aminoethyl-phosphorothioate (WR-2823) and 2-(3-aminopropyl)aminoethyl-phosphorothioate (WR-2721) as well as some of their "latent derivatives" (corresponding thiols and disulfides), labeled with 35 S and 32 P, were irradiated by a 400 Ci 137 Cs γ-ray source. The radiation products were separated, identified and measured quantitatively by paper chromatography. The radiolysis of these compounds brought about oxidation of the sulfur atom with subsequent dephosphorylation, and then further oxidation occurred to either the sulfonic acid or to inorganic sulfate. The oxidation of these radiation protective agents indicates that they are capable of reacting with radicals formed in irradiated aqueous solutions thus offering partial protection against irradiation induced changes. This protection was shown in two systems in vitro: (a) radiation-induced permeability of erythrocyte membranes and (b) radiation-induced decrease in specific viscosity of DNA solutions.
Radiation Research © 1973 Radiation Research Society