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Journal Article

# Heavy-Ion Irradiation of Human and Chinese Hamster Cells in Vitro

Paul W. Todd
Radiation Research
Vol. 61, No. 2 (Feb., 1975), pp. 288-297
DOI: 10.2307/3574046
Stable URL: http://www.jstor.org/stable/3574046
Page Count: 10
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## Abstract

Cultured human kidney (T-1) and liver (Chang) cells and Chinese hamster bone marrow (M3-1) cells were irradiated with heavy ions from the Berkeley heavy-ion linear accelerator, and their subsequent ability to grow into visible colonies was assessed. Heavy-ion inactivation cross sections were compared to microscopically measured nuclear cross section distributions found in cultures under the conditions of irradiation. Chinese hamster cells were found more resistant to all radiations studied within the linear energy-transfer range of $45-20,000\ {\rm MeV}\text{-}{\rm cm}^{2}/{\rm g}$ and this higher resistance relative to the human cells appeared to correlate with the smaller nuclear cross-sectional area of the Chinese hamster cells.

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