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A Comparison of the Radiation Sensitivities of Thymic and Thoracic Duct Lymphocytes

J. P. Geraci, G. M. Christensen and K. L. Jackson
Radiation Research
Vol. 61, No. 1 (Jan., 1975), pp. 158-163
DOI: 10.2307/3574066
Stable URL: http://www.jstor.org/stable/3574066
Page Count: 6
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A Comparison of the Radiation Sensitivities of Thymic and Thoracic Duct Lymphocytes
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Abstract

The dose-response curve for adenine incorporation, an index of cell death when measured 24 hr after irradiation, was biphasic for both thymic and thoracic duct lymphocyte populations X-irradiated in vitro. However, the magnitude of reduced adenine incorporation was greater for thymic lymphocytes than for thoracic duct lymphocytes at each dose examined. Measurement of the rate of injury development in the two cell populations indicates that the difference between the two dose-response curves is the result of a slower rate of injury development in thoracic duct lymphocytes. Correction for differences in rate of injury development indicates that the radiosensitivities of the two types of lymphocyte populations are identical.

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