## Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

## If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

# Association of Plutonium with Isolated Liver Parenchymal Cells Following Injection of Monomeric Plutonium into Mice

Maryka H. Bhattacharyya and Arthur Lindenbaum
Vol. 66, No. 3 (Jun., 1976), pp. 552-565
DOI: 10.2307/3574459
Stable URL: http://www.jstor.org/stable/3574459
Page Count: 14
Preview not available

## Abstract

The early kinetics of the association of plutonium with liver parenchymal cells was measured after intravenous injection of monomeric plutonium [${}^{239}{\rm Pu}({\rm IV})\text{citrate}$] into CF 1 female mice. The amount of plutonium associated with isolated liver parenchymal cells and the total liver plutonium concentration were determined at times ranging from 1 hr to 6 days after plutonium administration. The number of parenchymal cells per gram mouse liver as well as the ratios of parenchymal cell-associated plutonium (DPM/isolated cell) to total plutonium concentration (DPM/g liver) were calculated in order to determine the percentage of the liver burden associated with parenchymal cells. Up to 6 days, the concentration of monomeric plutonium associated with isolated mouse liver parenchymal cells increased more slowly than the total liver plutonium concentration. The latter reached a maximum by 5 hr and decreased only slightly by 6 days. In contrast, the fraction of the liver burden associated with parenchymal cells increased from 29% at 5 hr to 70% at 6 days after plutonium administration.

• 552
• 553
• 554
• 555
• 556
• 557
• 558
• 559
• 560
• 561
• 562
• 563
• 564
• 565