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Association of Plutonium with Isolated Liver Parenchymal Cells Following Injection of Monomeric Plutonium into Mice

Maryka H. Bhattacharyya and Arthur Lindenbaum
Radiation Research
Vol. 66, No. 3 (Jun., 1976), pp. 552-565
DOI: 10.2307/3574459
Stable URL: http://www.jstor.org/stable/3574459
Page Count: 14
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Association of Plutonium with Isolated Liver Parenchymal Cells Following Injection of Monomeric Plutonium into Mice
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Abstract

The early kinetics of the association of plutonium with liver parenchymal cells was measured after intravenous injection of monomeric plutonium [${}^{239}{\rm Pu}({\rm IV})\text{citrate}$] into CF 1 female mice. The amount of plutonium associated with isolated liver parenchymal cells and the total liver plutonium concentration were determined at times ranging from 1 hr to 6 days after plutonium administration. The number of parenchymal cells per gram mouse liver as well as the ratios of parenchymal cell-associated plutonium (DPM/isolated cell) to total plutonium concentration (DPM/g liver) were calculated in order to determine the percentage of the liver burden associated with parenchymal cells. Up to 6 days, the concentration of monomeric plutonium associated with isolated mouse liver parenchymal cells increased more slowly than the total liver plutonium concentration. The latter reached a maximum by 5 hr and decreased only slightly by 6 days. In contrast, the fraction of the liver burden associated with parenchymal cells increased from 29% at 5 hr to 70% at 6 days after plutonium administration.

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