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Influence of Localized Preinoculation Irradiation of the Foot on Lymphatic Metastasis from a Primary Tumor Growing in the Foot

D. S. Rappaport and J. M. Brown
Radiation Research
Vol. 78, No. 1 (Apr., 1979), pp. 108-121
DOI: 10.2307/3575011
Stable URL: http://www.jstor.org/stable/3575011
Page Count: 14
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Influence of Localized Preinoculation Irradiation of the Foot on Lymphatic Metastasis from a Primary Tumor Growing in the Foot
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Abstract

KHT tumor inoculated into the footpads of syngeneic C3H mice spontaneously metastasized primarily to the popliteal lymph node and secondarily to inguinal and lumbar nodes following a definite latent period. Lymph node weight was used to determine extent of metastasis to popliteal, inguinal, and lumbar lymph nodes. It was found that localized X-irradiation of the foot prior to tumor inoculation enhanced the extent of lymphatic metastasis to popliteal, and under certain conditions, inguinal and lumbar lymph nodes. The extent of enhancement was dependent on dose of irradiation and the interval of time between X-irradiation and tumor inoculation. Lung colony counts were elevated in a qualitatively similar manner. Possible mechanisms and implications for radiotherapy are discussed.

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