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Influence of Localized Preinoculation Irradiation of the Foot on Lymphatic Metastasis from a Primary Tumor Growing in the Foot
D. S. Rappaport and J. M. Brown
Vol. 78, No. 1 (Apr., 1979), pp. 108-121
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3575011
Page Count: 14
You can always find the topics here!Topics: Tumors, Lymph nodes, Metastasis, Irradiation, Inoculation, Lungs, Mice, Amputation, Cancer, Nodules
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KHT tumor inoculated into the footpads of syngeneic C3H mice spontaneously metastasized primarily to the popliteal lymph node and secondarily to inguinal and lumbar nodes following a definite latent period. Lymph node weight was used to determine extent of metastasis to popliteal, inguinal, and lumbar lymph nodes. It was found that localized X-irradiation of the foot prior to tumor inoculation enhanced the extent of lymphatic metastasis to popliteal, and under certain conditions, inguinal and lumbar lymph nodes. The extent of enhancement was dependent on dose of irradiation and the interval of time between X-irradiation and tumor inoculation. Lung colony counts were elevated in a qualitatively similar manner. Possible mechanisms and implications for radiotherapy are discussed.
Radiation Research © 1979 Radiation Research Society