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Bone Marrow Changes after Localized Acute and Fractionated X Irradiation
Anas M. El-Naggar, Ismail R. A. Hanna, Arjun D. Chanana, Arland L. Carsten and Eugene P. Cronkite
Vol. 84, No. 1 (Oct., 1980), pp. 46-52
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3575216
Page Count: 7
You can always find the topics here!Topics: Irradiation, Bone marrow, Megakaryocytes, Radiotherapy, Femur, Radiation dosage, Dose fractionation, Lymphocytes, Hematopoietic stem cells, Cell lines
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These studies were performed to compare the effects of single and fractionated localized irradiation doses to bone marrow on depletion and recovery of various hemopoietic cell lines. Mice received radiation to right thighs while the rest of the body was shielded. Single exposures ranged from 1000 to 10,000 rad and fractionated exposures ranged from total doses of 1000 to 6000 rad. Animals were sacrificed from 1 to 84 days after exposures. Stained sections of femurs were studied for total cellularity, megakaryocytes, immature cells (pro- and basophilic erythroblasts, myeloblasts, and promyelocytes), and lymphoid cells (lymphocytes and monocytes). In general, a dose-time-dependent response depletion pattern was seen for various cellular elements examined irrespective of the mode of radiation exposure. With fractionated schedules, all hemopoietic cell lines with the exception of megakaryocytes attained essentially control values by 12 weeks after the last radiation exposure irrespective of the total radiation dose. Megakaryocytes appeared to be less efficient in regenerating in and/or repopulating the exposed marrow. With single exposures, all hemopoietic cell lines examined failed to regenerate at radiation doses above 5000 rad.
Radiation Research © 1980 Radiation Research Society