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Bone Marrow Changes after Localized Acute and Fractionated X Irradiation

Anas M. El-Naggar, Ismail R. A. Hanna, Arjun D. Chanana, Arland L. Carsten and Eugene P. Cronkite
Radiation Research
Vol. 84, No. 1 (Oct., 1980), pp. 46-52
DOI: 10.2307/3575216
Stable URL: http://www.jstor.org/stable/3575216
Page Count: 7
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Bone Marrow Changes after Localized Acute and Fractionated X Irradiation
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Abstract

These studies were performed to compare the effects of single and fractionated localized irradiation doses to bone marrow on depletion and recovery of various hemopoietic cell lines. Mice received radiation to right thighs while the rest of the body was shielded. Single exposures ranged from 1000 to 10,000 rad and fractionated exposures ranged from total doses of 1000 to 6000 rad. Animals were sacrificed from 1 to 84 days after exposures. Stained sections of femurs were studied for total cellularity, megakaryocytes, immature cells (pro- and basophilic erythroblasts, myeloblasts, and promyelocytes), and lymphoid cells (lymphocytes and monocytes). In general, a dose-time-dependent response depletion pattern was seen for various cellular elements examined irrespective of the mode of radiation exposure. With fractionated schedules, all hemopoietic cell lines with the exception of megakaryocytes attained essentially control values by 12 weeks after the last radiation exposure irrespective of the total radiation dose. Megakaryocytes appeared to be less efficient in regenerating in and/or repopulating the exposed marrow. With single exposures, all hemopoietic cell lines examined failed to regenerate at radiation doses above 5000 rad.

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