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Journal Article

# Interaction of Oxygen and Nitroxyls with Radiation-Induced Radicals of DNA and Related Bases in Aqueous Solution

P. O'Neill, T. C. Jenkins and E. M. Fielden
Radiation Research
Vol. 82, No. 1 (Apr., 1980), pp. 55-64
DOI: 10.2307/3575236
Stable URL: http://www.jstor.org/stable/3575236
Page Count: 10
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## Abstract

The reaction of nitroxyl free radicals 2,2,6,6-tetramethylpiperidin-4-ol-N-oxyl (TMPN) and norpseudopelletierine-N-oxyl (NPPN) with peroxyl radicals derived from the · OH-adducts of DNA, thymine, and thymidylic acid has been investigated using pulse radiolysis. The results indicate that: (a) TMPN and NPPN react with the peroxyl radicals; (b) in the case of NPPN the resulting products, the optical absorption spectra of which were determined, are unstable and decay exponentially; and (c) native ${\rm DNA(OH)}^{\cdot}$ reacts with O2 with a rate constant $>10^{8}\ {\rm dm}^{3}\ {\rm mole}^{-1}\,{\rm sec}^{-1}$. In contrast to native DNA, where the optical absorption spectra for derived ${\rm DNA(OH)}^{\cdot}$ and ${\rm DNA}({\rm OH}){\rm O}{}_{2}{}^{\cdot}$ radicals are indistinguishable, denatured DNA affords analogous transient species the spectra of which differ markedly from one another.

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