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The Effect of Hyperthermia on Hemopoietic Progenitor Cells of the Mouse

Gary Van Zant, Dagmar Flentje and Michael Flentje
Radiation Research
Vol. 95, No. 1 (Jul., 1983), pp. 142-149
DOI: 10.2307/3576079
Stable URL: http://www.jstor.org/stable/3576079
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The Effect of Hyperthermia on Hemopoietic Progenitor Cells of the Mouse
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Abstract

We have studied the effect of heat on four lineage-specific clonogenic cells from mouse bone marrow. The thermal sensitivities of two red cell precursors, one primitive (BFU-E) and one more differentiated (CFU-E), a granulocyte-macrophage precursor (CFU-GM), and a megakaryocyte precursor (CFU-M) were determined after exposure to 42, 43, and 44°C. We found that the erythroid precursors were much more heat sensitive than either the CFU-GM or CFU-M. At 42°C the CFU-E and BFU-E had a D0 of about 30 min, while the CFU-GM and CFU-M had D0 values of about 60 min. Thus the four progenitors could be divided into two distinct classes with respect to their sensitivity to hyperthermia. These results suggest that erythropoiesis is more likely to be suppressed than either thrombopoiesis or leukocyte production when hyperthermia is applied in a clinical setting.

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