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The Effect of Hyperthermia on Hemopoietic Progenitor Cells of the Mouse
Gary Van Zant, Dagmar Flentje and Michael Flentje
Vol. 95, No. 1 (Jul., 1983), pp. 142-149
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3576079
Page Count: 8
You can always find the topics here!Topics: Granulocyte macrophage progenitor cells, Progenitor cells, Bone marrow, Stem cells, Hyperthermia, Blood cells, Pluripotent stem cells, Erythroid cells, Spleen cells, Bone marrow cells
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We have studied the effect of heat on four lineage-specific clonogenic cells from mouse bone marrow. The thermal sensitivities of two red cell precursors, one primitive (BFU-E) and one more differentiated (CFU-E), a granulocyte-macrophage precursor (CFU-GM), and a megakaryocyte precursor (CFU-M) were determined after exposure to 42, 43, and 44°C. We found that the erythroid precursors were much more heat sensitive than either the CFU-GM or CFU-M. At 42°C the CFU-E and BFU-E had a D0 of about 30 min, while the CFU-GM and CFU-M had D0 values of about 60 min. Thus the four progenitors could be divided into two distinct classes with respect to their sensitivity to hyperthermia. These results suggest that erythropoiesis is more likely to be suppressed than either thrombopoiesis or leukocyte production when hyperthermia is applied in a clinical setting.
Radiation Research © 1983 Radiation Research Society