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Effects of ${}^{89}{\rm Sr}$ on the Production and Maturation of Small Lymphocytes Bearing Surface Immunoglobulin, Fc, and Complement Receptors in Mice

F. P. H. Chan and B. E. Ens
Radiation Research
Vol. 97, No. 3 (Mar., 1984), pp. 576-586
DOI: 10.2307/3576149
Stable URL: http://www.jstor.org/stable/3576149
Page Count: 11
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Effects of ${}^{89}{\rm Sr}$ on the Production and Maturation of Small Lymphocytes Bearing Surface Immunoglobulin, Fc, and Complement Receptors in Mice
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Abstract

Ten-week-old C57B1/6J mice were given an intraperitoneal injection of 100 μCi radiostrontium $({}^{89}{\rm Sr})$. One and two weeks following injection, the cellular composition of marrow and spleen was examined for cellularity, types of lymphoid cells, and incidences of small lymphocytes bearing sIgM, FcR, and CR. Strontium-89 treatment yielded a significant cell depletion in marrow, whereas spleen cellularity initially increased before returning to normal level in the second week. The increase in spleen cellularity was showed by pulse DNA labeling to be due to local production and not to influx from elsewhere. The percentage of medium and large lymphocytes, precursors of small lymphocytes, increased from 4% in the control spleen to 22% in the ${}^{89}{\rm Sr}\text{-treated}$ spleen. The incidences of small lymphocytes bearing sIgM, FcR, and CR were lower than normal levels with the exception of a substantial increase of ${\rm FcR}^{+}$ small lymphocytes in the spleen 2 weeks following ${}^{89}{\rm Sr}$ injection. Double-labeling studies, combining rosetting for surface receptors and DNA labeling for cell age, showed that small lymphocytes bearing sIgM, FcR, and CR form part of the major population of indigenous rapidly renewed cells in ${}^{89}{\rm Sr}\text{-treated}$ spleen.

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