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The Response of Previously Irradiated Skin to Combinations of X Radiation and Ultrasound-Induced Hyperthermia
Donald G. Baker, Holliday Sager, William Constable and Nigel Goodchild
Vol. 96, No. 2 (Nov., 1983), pp. 367-373
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3576219
Page Count: 7
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Areas of skin approximately 1.5 cm in diameter on the legs of mice were made hyperthermic (30 min at 42.7°C) by exposure to an ultrasound beam (780 kHz), a single dose of X irradiation (2000 rad), or a combination of these treatments. After 35 days, when the acute reaction had reached a steady state, the same tissue was given a second treatment by either hyperthermia, irradiation, or a combination of hyperthermia and irradiation. When the first treatment was irradiation and the second treatment was either irradiation or a combination of hyperthermia and irradiation, the acute skin reactions were similar to those of skin not previously irradiated, indicating a large proportion of recovery from the first irradiation. When irradiation was the first treatment, a comparison of second treatments by hyperthermia plus irradiation with irradiation alone showed a thermal enhancement of 1.45. When the first treatment was hyperthermia plus irradiation, a comparison of second treatments by hyperthermia plus irradiation with irradiation also showed an enhancement factor of 1.45 for the combined treatment.
Radiation Research © 1983 Radiation Research Society