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G2 Cells: Progression Delay and Survival

Martin H. Schneiderman and G. S. Schneiderman
Radiation Research
Vol. 98, No. 2 (May, 1984), pp. 389-396
DOI: 10.2307/3576246
Stable URL: http://www.jstor.org/stable/3576246
Page Count: 8
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G2 Cells: Progression Delay and Survival
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Abstract

The progression of Chinese hamster ovary (CHO) G2 cells into mitosis and their survival was measured after X-ray doses up to 4.0 Gy. S-phase cells were prevented from reaching mitosis by labeling with 125 IUdR for 10 min prior to irradiation of the exponentially growing monolayer of cells. Mitotic cells, located past the radiation-induced division delay transition point, did not suffer a delay and were selected separately prior to the recovery of the G2 cells. The results show that (1) up to 400 min after radiation only 55% of the G2 cells recovered after about 2.5 Gy; (2) the progression delay of the G2 cells that recovered was 52.5 min/Gy; and (3) the survival curve D0 for these cells, 2.45 Gy, indicated a radioresistant population.

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