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Relative Biological Effectiveness Measurements Using Murine Lethality and Survival of Intestinal and Hematopoietic Stem Cells after Fermilab Neutrons Compared to JANUS Reactor Neutrons and 60 Co Gamma Rays

W. R. Hanson, D. A. Crouse, R. J. M. Fry and E. J. Ainsworth
Radiation Research
Vol. 100, No. 2 (Nov., 1984), pp. 290-297
DOI: 10.2307/3576350
Stable URL: http://www.jstor.org/stable/3576350
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Relative Biological Effectiveness Measurements Using Murine Lethality and Survival of Intestinal and Hematopoietic Stem Cells after Fermilab Neutrons Compared to JANUS Reactor Neutrons and 60 Co Gamma Rays
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Abstract

The relative biological effectiveness (RBE) of the 25-MeV (average energy) neutron beam at the Fermi National Accelerator Laboratory was measured using murine bone marrow (${\rm LD}_{50/30}$) and gut (${\rm LD}_{50/6}$) lethality and killing of hematopoietic colony forming units (CFU-S) or intestinal clonogenic cells (ICC). The reference radiation was 60 Co γ rays. The ${\rm LD}_{50/30}$ and ${\rm LD}_{50/6}$ for mice exposed to the Fermilab neutron beam were 6.6 and 8.7 Gy, respectively, intermediate between those of JANUS neutrons and 60 Co γ rays. The D0 values for CFU-S and ICC were 47 cGy and 1.05 Gy, respectively, also intermediate between the lowest values found for JANUS neutrons and the highest values found after 60 Co γ rays. The split-dose survival ratios for CFU-S at intervals of 1-6 hr between doses were essentially 1.0 for both neutron sources, while the corresponding split-dose survival ratio for 60 Co γ rays was consistantly above 1, reaching a maximum of 1.7 with a 1-hr interval between doses. The 3-hr split-dose survival ratios for ICC were 1.0 for JANUS neutrons, 1.85 for Fermilab neutrons, and 6.5 for 60 Co γ rays. The RBE estimates for ${\rm LD}_{50/30}$ were 1.5 and 2.3 for Fermilab and JANUS neutrons, respectively. Based on ${\rm LD}_{50/6}$, the RBEs were 1.9 (Fermilab) and 3.0 (JANUS). The RBEs for CFU-S D0 were 1.4 (Fermilab) and 1.9 (JANUS) and for jejunal microcolony D0 1.4 (Fermilab) and 2.8 (JANUS).

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