Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Analysis of Dose-Incidence Relationships for Marrow Failure in Different Species, in Terms of Radiosensitivity of Tissue-Rescuing Units

J. H. Hendry and S. A. Roberts
Radiation Research
Vol. 122, No. 2 (May, 1990), pp. 155-160
DOI: 10.2307/3577600
Stable URL: http://www.jstor.org/stable/3577600
Page Count: 6
  • Read Online (Free)
  • Download ($10.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Analysis of Dose-Incidence Relationships for Marrow Failure in Different Species, in Terms of Radiosensitivity of Tissue-Rescuing Units
Preview not available

Abstract

The analysis of 68 published sets of dose-incidence data for marrow failure in different species, using a double-log mortality function, indicates: (a) There is more heterogeneity, i.e. greater sums-of-squares per degree of freedom, within the data sets for mouse than for larger species (monkey, dog, sheep, goat, pig). (b) For mice the curves for acute doses are characterized by a D0 of about 100 cGy for tissue-rescuing units (or target cells), which are depleted at most to about 3× 10-4 at LD50. (c) Larger species are much less tolerant to target-cell depletion, the corresponding level being consistently in the range of $10^{-2}-10^{-3}$ at LD50. Also, the D0 is often lower (∼55 cGy), which is compatible in the dog with such a value for hemopoietic progenitor cells. (d) With larger species there is an unexpected reduction in heterogeneity when the dose rate is lower, which gives a D0 lower than expected and a higher extrapolate. It is concluded that the position and slope of the dose-incidence curves are compatible with interpretations based primarily on target-cell number and survival characteristics, modified by additional heterogeneity factors.

Page Thumbnails

  • Thumbnail: Page 
155
    155
  • Thumbnail: Page 
156
    156
  • Thumbnail: Page 
157
    157
  • Thumbnail: Page 
158
    158
  • Thumbnail: Page 
159
    159
  • Thumbnail: Page 
160
    160