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Radiation-Induced Endometriosis in Macaca mulatta
John W. Fanton and John G. Golden
Vol. 126, No. 2 (May, 1991), pp. 141-146
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3577812
Page Count: 6
You can always find the topics here!Topics: Endometriosis, Protons, Cysts, Lesions, Monkeys, Radiation dosage, Female animals, Solar X rays, Adhesion, Electrons
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Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (χ 2, P < 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidences of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.
Radiation Research © 1991 Radiation Research Society