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A Morphological Study of Radiation Nephropathy in the Pig

Mike E. C. Robbins, M. J. A. Wooldridge, R. S. Jaenke, E. Whitehouse, S. J. Golding, M. Rezvani and J. W. Hopewell
Radiation Research
Vol. 126, No. 3 (Jun., 1991), pp. 317-327
DOI: 10.2307/3577921
Stable URL: http://www.jstor.org/stable/3577921
Page Count: 11
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Morphological Study of Radiation Nephropathy in the Pig
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Abstract

Both kidneys of mature pigs received a single dose of 9.8 Gy 60 Co γ rays. Pigs were killed between 2 and 24 weeks after irradiation and the kidneys examined histologically. Glomerular and tubular changes were observed within 2 weeks of irradiation. Neutrophils and other leukocytes were seen within glomerular capillary loops; mesangial matrix and cell number increased. A progressive increase in thickening of the basement membrane and a decrease in capillary lumina were then noted. Basement membrane duplication occurred within 12 weeks. By 24 weeks these lesions had increased in severity, sclerotic end-stage glomeruli, predominantly subcapsular or juxtamedullary, being evident. Tubular lesions initially consisted of focal areas of tubular atrophy in the juxtamedullary region. By 6 weeks subcapsular foci of tubular degeneration, regeneration, and necrosis were found; these appeared to resolve 12 weeks after irradiation. At later times the severity of the tubular lesions varied between pigs, with some exhibiting interstitial fibrosis involving a complete band of subcapsular tissue, while others showed relatively mild changes. There was no apparent change in the vasculature. These findings indicate that (a) there is no one target or dose-limiting cell, and (b) the vasculature does not play a primary role in the development of radiation nephropathy.

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