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Cell Cycle-Dependent Expression of Ki-67 Antigen in Human Melanoma Cells Subjected to Irradiation and/or Hyperthermia

F. Zölzer and C. Streffer
Radiation Research
Vol. 143, No. 1 (Jul., 1995), pp. 98-101
DOI: 10.2307/3578931
Stable URL: http://www.jstor.org/stable/3578931
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Cell Cycle-Dependent Expression of Ki-67 Antigen in Human Melanoma Cells Subjected to Irradiation and/or Hyperthermia
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Abstract

The proliferation of human melanoma cells in vitro during the first 3 days after irradiation and/or hyperthermia was followed by two-parameter flow cytometry combining cell cycle analysis on the basis of DNA content with Ki-67 antibody labeling. It was found that cells arrested or delayed in the S and G2 phases of the cell cycle were Ki-67-positive in spite of the antigen's very short half-life. Thus Ki-67 staining failed to reflect those changes in cell proliferation which typically occur in the course of a fractionated radiotherapy as well as those expected in the case of hyperthermia or a combined treatment.

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