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Decreased Incidence of Thymic Lymphoma in AKR Mice as a Result of Chronic, Fractionated Low-Dose Total-Body X Irradiation
Keiichiro Ishii, Yoshio Hosoi, Shougo Yamada, Tetsuya Ono and Kiyohiko Sakamoto
Vol. 146, No. 5 (Nov., 1996), pp. 582-585
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3579560
Page Count: 4
You can always find the topics here!Topics: Lymphoma, Irradiation, Tumors, Non Hodgkin lymphoma, T lymphocytes, Radiotherapy, Lymphocytes, Medical research, Research universities, Life span
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We have investigated whether low-dose total-body X irradiation could suppress the development of lymphoma in AKR mice. Male mice were irradiated with 5 cGy three times a week or 15 cGy two times a week from 11 weeks of age for 40 weeks. The incidences of lymphoma were 80.5% in sham-irradiated mice, 67.5% in mice irradiated with 5 cGy three times a week and 48.6% in mice irradiated with 15 cGy twice a week. Incidence of lymphoma was significantly reduced by irradiation with 15 cGy twice a week (P = 0.006). The mean survival time was significantly prolonged from 283 ± 3 days in control mice to 316 ± 10 days in mice irradiated with 15 cGy twice a week (P = 0.008) and to 309 ± 14 days in mice irradiated with 5 cGy three times a week (P = 0.040). Because about 80% of male AKR mice die of lymphoma, it is likely that the prolonged life span observed in the irradiated mice is due to the reduced incidence of lymphoma.
Radiation Research © 1996 Radiation Research Society