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How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

Mary Helen Barcellos-Hoff
Radiation Research
Vol. 150, No. 5, Supplement: Madame Curie's Discovery of Radium (1898): A Commemoration by Women in Radiation Sciences (Nov., 1998), pp. S109-S120
DOI: 10.2307/3579813
Stable URL: http://www.jstor.org/stable/3579813
Page Count: 12
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues
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Abstract

The capacity of ionizing radiation to affect tissue function, control tumor growth and elicit pathological sequelae has been attributed in great part to its effects on cellular DNA, which, as the transmitter of genetic information, can both register damage and perpetuate it. Nonetheless, multicellular organisms function as the result of the cooperation of many cell types. What then occurs when individual cells are damaged by ionizing radiation? It tissue response a sum of cellular effects such as cell death and DNA damage? Or does the tissue respond as a coherent unit to the damage of its parts? In this paper, data in support of the latter model that indicate a role for cytokines, in particular transforming growth factor β1, as critical components of extracellular signaling pathways that mediate tissue response to radiation will be reviewed. The key to manipulating the consequences of radiation exposure lies in understanding the complex interplay of events initiated at the cellular level, but acting on the tissue.

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