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Pathology of Radium-Induced Bone Tumors: New Aspects of Histopathology and Histogenesis

Wolfgang Gössner
Radiation Research
Vol. 152, No. 6, Supplement: The International Workshop on the Health Effects of Thorotrast, Radium, Radon and Other Alpha-Emitters 1999 (Dec., 1999), pp. S12-S15
DOI: 10.2307/3580104
Stable URL: http://www.jstor.org/stable/3580104
Page Count: 4
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Pathology of Radium-Induced Bone Tumors: New Aspects of Histopathology and Histogenesis
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Abstract

A revision of bone tumor pathology in patients treated with multiple injections of the short-lived α-particle emitter radium-224, predominantly for tuberculosis and ankylosing spondylitis, revealed an unexpectedly high proportion of bone sarcomas of the fibrous connective tissue type. This included the first case of malignant fibrous histiocytoma of bone described after internal irradiation. A comparison of bone tumor types in the radium-224 patients and bone sarcoma after incorporation of radium-226 and radium-228 and external irradiation and in tumors arising at sites of pre-existing bone lesions showed the same spectrum of tumors. The high incidence of bone tumors of the fibroblastic and fibrohistiocytic type was observed in all these "secondary" bone sarcomas. These results suggest that a close histogenetic relationship exists between disorder of the local milieu caused by deterministic radiation damage accompanied by disturbances of the remodeling process. The reactive proliferation of the predominantly fibroblastic tissue could be the presumptive origin of these special types of radiation-induced bone sarcomas.

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