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Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization
Marianne Chomentowski, Albrecht M. Kellerer and Donald A. Pierce
Vol. 153, No. 3 (Mar., 2000), pp. 289-294
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/3580291
Page Count: 6
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The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. This is usually complemented by a more direct visualization where the data are subdivided into distinct dose categories and the effect level is quantified for each of these categories. Such model-free computations, however, can be quite dependent on the arbitrary choice of the cutpoints in dose. The method proposed here largely avoids this arbitrariness by choosing a dose category width-constant on a log scale-to obtain the desired degree of smoothing, and then superimposing results for all placements of the resulting log-dose grids. The method is applied to leukemia and solid cancer mortality of the A-bomb survivors.
Radiation Research © 2000 Radiation Research Society