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Motorneuron Pools Innervating Muscles in Vitamin A-Induced Proximal--Distal Duplicate Limbs in the Axolotl
N. Stephens, N. Holder and M. Maden
Proceedings of the Royal Society of London. Series B, Biological Sciences
Vol. 224, No. 1236 (May 22, 1985), pp. 341-354
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/35881
Page Count: 15
You can always find the topics here!Topics: Axons, Innervation, Nerves, Muscles, Vitamin A, Forelimbs, Nerve regeneration, Synapses, Amputation, Signals
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Serially duplicated limbs containing two sets of proximal muscles were created in axolotls by vitamin A treatment. The innervation of three replicated proximal muscles was studied by using retrograde transport of horseradish peroxidase. These were the forelimb muscles biceps (seven cases) and anconeus (five cases) and the hindlimb muscle puboischiotibialis (five cases). In two cases (both of anconeus) innervation was from a correct motorneuron pool. In the other 15 cases the innervation was from an incorrect, distal limb muscle, motorneuron pool. These results are interpreted as evidence against long range signals between nerve and muscle controlling specific nerve regeneration. However, the data are compatible with models of axonal guidance that use local pathway cues.
Proceedings of the Royal Society of London. Series B, Biological Sciences © 1985 Royal Society