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AnBMP2/4 Is a New Member of the Transforming Growth Factor-β Superfamily Isolated from a Crinoid and Involved in Regeneration

M. Patruno, I. McGonnell, A. Graham, P. Beesley, M. D. Candia Carnevali and M. Thorndyke
Proceedings: Biological Sciences
Vol. 270, No. 1522 (Jul. 7, 2003), pp. 1341-1347
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/3592302
Page Count: 7
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AnBMP2/4 Is a New Member of the Transforming Growth Factor-β Superfamily Isolated from a Crinoid and Involved in Regeneration
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Abstract

Invertebrates have frequently been used to help understand the complexities of regulatory gene function and evolution. The bone morphogenetic proteins (BMPs) are a highly conserved group of secreted regulatory factors that play an important part in early embryonic patterning. In the present study we have used the remarkable regenerative potential of crinoid echinoderms to explore the BMPs' site of expression in an adult developmental programme. Our results suggest that a crinoid BMP2/4 homologue is actively involved during the early stages of blastemal regeneration at a time when fundamental patterns are being established. This supports the idea of an evolutionary developmental programme where essential gene families are conserved throughout phylogeny in terms of both expression and function.

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