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It's HIP to Be a Hub: New Trends for Old-Fashioned Proteins

Manuela Vecchi and Pier Paolo Di Fiore
The Journal of Cell Biology
Vol. 170, No. 2 (Jul. 18, 2005), pp. 169-171
Stable URL: http://www.jstor.org/stable/3658376
Page Count: 3
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It's HIP to Be a Hub: New Trends for Old-Fashioned Proteins
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Abstract

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

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