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Terminating Wnt Signals: A Novel Nuclear Export Mechanism Targets Activated β-Catenin

Meghan E. Thorne and Cara J. Gottardi
The Journal of Cell Biology
Vol. 171, No. 5 (Dec. 5, 2005), pp. 761-763
Stable URL: http://www.jstor.org/stable/3658507
Page Count: 3
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Terminating Wnt Signals: A Novel Nuclear Export Mechanism Targets Activated β-Catenin
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Abstract

Nuclear targeting of β-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes β-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of β-catenin. We speculate that cells may use multiple export mechanisms to inhibit β-catenin signaling in different ways.

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