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Identification of Metabolites Produced from Acridine by Cunninghamella elegans

John B. Sutherland, Frederick E. Evans, James P. Freeman, Anna J. Williams, Joanna Deck and Carl E. Cerniglia
Mycologia
Vol. 86, No. 1 (Jan. - Feb., 1994), pp. 117-120
DOI: 10.2307/3760726
Stable URL: http://www.jstor.org/stable/3760726
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Identification of Metabolites Produced from Acridine by Cunninghamella elegans
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Abstract

Mycelia of Cunninghamella elegans were incubated in liquid Sabouraud medium containing 56 μm acridine. After 3 days, the culture medium was extracted with ethyl acetate and two metabolites were purified by high-performance liquid chromatography. Acridine trans-1,2-dihydrodiol and 2-hydroxyacridine were identified by ultraviolet-visible absorption spectrophotometry, mass spectrometry, and proton nuclear magnetic resonance spectroscopy. The data support a proposed pathway in which acridine is oxidized to a transient arene oxide, which is then hydrated to form the dihydrodiol or rearranged to form the phenol.

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