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Identification of Metabolites Produced from Acridine by Cunninghamella elegans
John B. Sutherland, Frederick E. Evans, James P. Freeman, Anna J. Williams, Joanna Deck and Carl E. Cerniglia
Vol. 86, No. 1 (Jan. - Feb., 1994), pp. 117-120
Published by: Mycological Society of America
Stable URL: http://www.jstor.org/stable/3760726
Page Count: 4
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Mycelia of Cunninghamella elegans were incubated in liquid Sabouraud medium containing 56 μm acridine. After 3 days, the culture medium was extracted with ethyl acetate and two metabolites were purified by high-performance liquid chromatography. Acridine trans-1,2-dihydrodiol and 2-hydroxyacridine were identified by ultraviolet-visible absorption spectrophotometry, mass spectrometry, and proton nuclear magnetic resonance spectroscopy. The data support a proposed pathway in which acridine is oxidized to a transient arene oxide, which is then hydrated to form the dihydrodiol or rearranged to form the phenol.
Mycologia © 1994 Mycological Society of America